Journal: PLoS Genetics
Article Title: HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity
doi: 10.1371/journal.pgen.1006984
Figure Lengend Snippet: (A and B) Annotated ECG curve of the HSPB7 CKO and control animals before (A) and 7 days after (B) the first tamoxifen injection. (C and D) Quantification of the ECG changes in HSPB7 CKO and control animals before (C) and 7 days after (D) the first tamoxifen administration. N = 5 per group. Data are presented as means ± SD. *, P < 0.05 **, P < 0.01 relative to the control. (E) Representative telemetric 2-lead ECG recording of a tamoxifen-treated HSPB7 CKO and control mice. Telemetry ECG recordings of lethal arrhythmias in HSPB7 CKO mice. n = 2 per group.
Article Snippet: For telemetric measurement of the ECG, miniature telemetry transmitter devices (HD-X11, Data Sciences International) were implanted subcutaneously on the back with electrodes surgically placed and sutured to the right of the trachea and the left upper abdominal region as described [ ].
Techniques: Control, Injection